Libin bioengineering and electrophysiology research collaboration makes cover of Heart Rhythm Journal


Congratulations to Patrick M. Boyle, PhD, George D. Veenhuyzen, MD, and Edward J. Vigmond, PhD on making the cover of the March issue of Heart Rhythm, the official journal of the Heart Rhythm Society.

“Fusion during entrainment of orthodromic reciprocating tachycardia is enhanced for basal pacing sites but diminished when pacing near Purkinje system end points”(Heart Rhythm, Volume 10, Issue 3 , Pages 444-451, March 2013) is the result of the collaboration between bioengineers Vigmond and Boyle (now a post-doc at Johns Hopkins and Libin Institute alumni who completed his PhD here in 2011 under the supervision of Ed Vigmond) and Dr. George D. Veenhuyzen, an electrophysiologist and clinical assistant professor at the University of Calgary.

“My previous research has been in using pacing maneuvers in the EP lab to arrive at a correct diagnosis for the mechanism of supraventricular tachycardia,” says Veenhuyzen. His previous work showed that a useful finding was often—but not always—available when pacing close to the base of the heart.

Working with the bioengineers to design a computer model of supraventricular tachycardia, Veenhuyzen used this model to explore why this finding was not always available. The model was novel for this arrhythmia, and offers an opportunity to test findings with a variety of pacing sites without having to do this in a cumbersome and time consuming manner in patients.

“We discovered that an important potential explanation for why the useful diagnostic finding was not always present when pacing close to the base of the heart was that some people may have a portion of their heart’s electrical conduction system close to the base of the heart,” he says. “This now offers an opportunity to test whether this is true in human hearts.”


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