Libin scientists identify new marker for heart disease

Published research led by Libin Cardiovascular Institute of Alberta Director Dr. Todd J. Anderson finds that endothelial dysfunction (blood vessel lining) can predict who is at risk for developing coronary heart disease. Specifically, lower blood velocity in the brachial artery of the arm as measured after a period of reduced flow induced by a blood pressure cuff, was shown to be a significant additive predictor to previously well recognized Framingham measures. This is the first time hyperemic velocity, a measure of microvascular function, has been demonstrated as a predictor in a long-term study.

Dr.Francois Charbonneau (L), Heather Conradson (M), and Dr. Todd Anderson (R) watch as Calgary firefighter Wayne Morris gets a bracial ultrasound.

This study builds on work Dr. Anderson conducted over a period of two decades. Of particular note, it builds on a paper he authored in 1995 that demonstrated the relationship of endothelial function in coronary circulation to that of endothelial function in the arm. That paper has been cited by researchers approximately 1,400 times – a phenomenal number for a single paper and a demonstration of it forming the basis of research happening around the world.

More reading …

Article published January 2011 in Circulation, a journal of the American Heart Association: Microvascular Function Predicts Cardiovascular Events in Primary Prevention

Dr. Anderson’s foundational article published 1995 in the Journal of the American College of Cardiology: Close relation of endothelial function in the human coronary and peripheral circulations

Sample media coverage:

CBC Radio interview, BT Calgary video, BT article, Edmonton Journal, Global News, Global TV Health FYI, Calgary Herald article and video, MedIndia, EurekAlert, UCalgary Medicine

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